Abstract : Science can be subdivided into many disciplines, major three are Chemical (Physics & Chemistry), Biology (Botany & Zoology) and Earth Sciences (Geology and Astronomy). Human wellbeing has contributions from all the branches of science, some very obvious (like Chemistry) and others not so conspicuous (for example Astronomy). Life expectancy of humans has doubled in the last hundred years due to the contributions of scientists. With improvements in medicare and personal hygiene, humans on an average live upto ~70 years worldwide whereas the average age was ~35 years in the last century. Good health encompasses prevention of diseases, early and accurate diagnosis, total cure and preferentially, personalised medicine. Molecules as small as Aspirin to big ones like antibodies and proteins have been used for treatment of diseases. Details on ‘Role of Science in Human Well-being’ will be presented.