Development of drug resistance is a major obstacle against successful chemotherapy of many currently-used anticancer drugs in clinics as the resistance often leads to recurrence of the disease. CIL-102, a plant (Zanthoxylum simulans) derived alkaloid is highly potent against multi-drug resistant cancer. We have identified the cellular target of CIL-102 and unraveled the mechanisms of action of the drug in breast cancer cells. Our findings suggest that CIL-102 may be considered as a potential lead compound in anticancer therapy, especially against chemo-resistant cancer.
Indian Institute of Science Education and Research, Thiruvananthapuram (IISER-TVM) is dedicated to scientific research and science education of international standards.