The surface of the cell is highly dynamic and heterogeneous. It can spatiotemporally regulate its local composition and shape to interact with the outside world. I will discuss how active mechanical stresses and currents generated on the surface determines the organization of cell surface molecules. These stresses and currents which occur due to contractility and treadmilling of active filaments on the surface of cells can drive molecular clustering, while remodelling of the filaments makes things transient. I will discuss its consequences on the spatiotemporal regulation of chemical reactions on the cell surface. Finally using athermodynamic model, I will show how clustering on the cell surface could affect cellular uptake of nanoparticles which have been used extensively for drug delivery purposes.