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Indian Institute of Science Education and Research
Thiruvananthapuram

Prof S. Murty Srinivasula
Professor (HAG) (Biology)
  +91 (0)471 - 2778171
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Selected Publications:

  1. Narendradev, Nikhil Dev; Marathe, Soumitra; Baboo, Sabyasachi; McClatchy, Daniel; Diedrich, Jolene; Jain, Parul; Purwar, Rahul; Yates III, John; Srinivasula SM, (2025). Quantitative proteomic analysis reveals JMJD6 and DNAJB11 as endogenous substrates of E3 ligase RFFL. Journal of Proteome Research. June https://pubs.acs.org/doi/10.1021/acs.jproteome.5c00086. 
  2. Narendradev, N.D, Ravindran R., Jain P., Chaudhary S., Velikkakath, A. K. G, Sudharman A., Janardhanan A., Nag T. C., Yadav S. C., & Srinivasula SM. (2025). Endosomal RFFL ubiquitin ligase regulates mitochondrial morphology by targeting Mitofusin 2. Journal of Cell Science, 138 (12), jcs 263830 (Cover page)
  3. Anusree Krishna, Anupama Babulal, Mareena Sajeev, Nidhin Ravi, Gowtham Raj, Anitta Antony, Nikhil Dev Narendradev, Srinivasula SM, Reji Varghese (2025). Chemistry, 31(13) e202404068.
  4. K Swetha, Anushree Bhatnagar, Manikrishna Lakavathu, Poornima Penta, Prathiksha Ganesh, Adithi Kamath, Srinivasa Reddy Bonam, Srinivasula SM, Rajendra Kurapati (2025). Biological Degradation of Graphitic Carbon Nitride Sheets and Autophagy Induction in Macrophages. Nanoscale, (in press).
  5. Sharma R, Mondal P, Srinivasula SM. (2024). EGF-mediated Golgi dynamics and cell migration require CARP2. Cell Reports, 43(11):114896
  6. Anushree Bhatnagar, Umesh Chopra, Sebastian Raja, Krishanu Dey Das, S Mahalingam, Dipshikha Chakravortty, & Srinivasa Murty Srinivasula (2024). TLR-mediated aggresome-like induced structures comprise antimicrobial peptides and attenuate intracellular bacterial survival. Molecular Biology of the Cell, 35 (3), ar34.
  7. K. S., A., Sarkar, S., Vishnu, S., S. R., R., Negi, S., Narendradev, N. D., Arora, R. H., Sanam, S., P. V., A., Sharma, R., Khurana, S., Varghese, J., Srinivasula SM, & Singh, M. S. (2024). Real-time study of spatio-temporal dynamics (4D) of physiological activities in alive biological specimens with different FOVs and resolutions simultaneously. Scientific Reports, 14(1), 3542.
  8. Raj, G., D. S, V., Prasad, J., Anbu, E., Ram, S., Daniel, G. B., Narendradev, N. D., Srinivasula SM.,Varghese, R. (2024). Antisense DNA loaded 2D nanosheets for combined photodynamic and antisense cancer therapy. Materials Chemistry Frontiers, 8 (2), 553-561.
  9. Raj, G., D. S., V., Narendradev, N. D., Dommeti, V. K. K., Shriwas, S., Ajay Sekhar, P. M., Jacob, L. S., Srinivasula SM., Varghese, R. (2023). Tumor microenvironment responsive nanocarriers for efficient antisense DNA delivery and enhanced chemodynamic therapy. Materials Chemistry Frontiers, 7 (9),1821-1830. 
  10. Sharma R, Mondal P, Srinivasula SM. (2023). CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono-ubiquitination. The FEBS Journal 290 (14), 3580-3594. 
  11. Ravindran, R., Velikkakath, A. K. G., Narendradev, N. D., Chandrasekharan, A., Santhoshkumar, T. R., & Srinivasula SM. (2022). Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria. Autophagy (pp. 1–14). Informa UK Limited. 
  12. Rafeeka, R. S., Kurup, A., Roy, D., Nongthomba, U., Srinivasula SM., & Singh, M. S. (2022). Design and instrumentation of simultaneous multiple-level magnification selective plane illumination microscopy: a cost-effective imaging system for biological applications. Optical Engineering (Vol. 61, Issue 04). SPIE-Intl Soc Optical Eng. 
  13. S R, R., Chitre, K., Kurup, A., Nongthomba, U., Srinivasula SM, & Suheshkumar Singh, M. Simultaneous multiple-level magnification selective plane illumination microscopy (sMx-SPIM) imaging system. Journal of Optics (2022). (Vol. 24, Issue 2, p. 024010). IOP Publishing. 
  14. Reselammal, D. S., Pinhero, F., Sharma, R., Hassan, M. S. O., Srinivasula SM., & Vijayan, V. Mapping the fibril core of the prion subdomain of the mammalian CPEB3 that is involved in long term memory retention. (2021). Journal of Molecular Biology, 433(15), 167084.
  15. Parvathy R Suma, Renjini A Padmanabhan, Srinivasa Reddy Telukutla , Rishith Ravindran, Anoop Kumar G Velikkakath, Chaitali D Dekiwadia, Willi Paul, Malini Laloraya, Srinivasula SM, Sheshanath V Bhosale Ramapurath S Jayasree . Vanadium pentoxide nanoparticle mediated perturbations in cellular redox balance and the paradigm of autophagy to apoptosis. Free Radic Biol Med (2020) 161:198-211.
  16. Nair SV, Narendradev ND, Nambiar RP, Kumar R, Srinivasula SM. Naturally occurring and tumor-associated variants of RNF167 promote lysosomal exocytosis and plasma membrane resealing. J Cell Sci. (2020) 133(11) jcs239335.
  17. Hari Veera Prasad Thelu, Shine K. Albert, Murali Golla, Nithiyanandan Krishnan, Divya Ram,Srinivasula SM and Reji Varghese. Size controllable DNA nanogels from the self-assembly of DNA nanostructures through multivalent host–guest interactions Nanoscale, 2018, 10, 222–230
  18. H.V. P. Thelu, S. K. Albert, M. Golla, N. Krishnan, S. B. Yamijala, Sreeja V. Nair, Srinivasula SM and Reji Varghese, (2016), DNA-Decorated Luminescent Vesicles as Drug Carriers.  Chemistry Select, 1, 5388.
  19. Srinivasula SM and Ashwell JD. (2011). A20: More than one way skin a cat. Mol. Cell, 44: 511-512.
  20. Fujita K and Srinivasula SM. (2011). TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy, 7: 29-31.
  21. Fujita K, Xiao Q, Maeda D and Srinivasula SM. (2011). Nrf2-mediated induction of p62 controls TLR4-driven ALIS formation and autophagic degradation, Proc Nat Acad Sci, USA, 108: 1427-32.
  22. Shukla S, Fujita K, Xiao Q, and Srinivasula SM. (2011). A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface. Apoptosis, 16: 162-173.
  23. Liao, W, Fujita K, Xiao Q, Tchikov V, Yang W, Gunsor, M, Garfield S, Goldsmith, P. El-Deiry WS, Schutze S, and Srinivasula SM. (2009). CARP1 Regulates Induction of NF-kB by TNF-a. Current Biology. 19: R17-R19
  24. Srinivasula, SM, and Ashwell, JD (2008). IAPs: What’s in a name? Mol Cell. 30: 123-35.
  25. Liao, W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Schutze S, El-Deiry WS, and Srinivasula SM. (2008). CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-?B activation. Current Biology. 18: 641-9.
  26. Srinivasula SM, Jones JM., Datta P., Ji W., Gupta S., Zhang Z., Davies E., Hajnóczky G., Saunders TL., Van Keuren ML., Alnemri T., Meisler ML and Alnemri ES. (2003). Loss ofOmi/HtrA2 protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature. 425: 721-727.
  27. Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES. (2003). Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2. J Biol Chem. 278: 31469-72.
  28. Srinivasula SM, Datta P, Kobayashi M, Wu J-W, Fujioka M, Hegde R, Zhang Z, Mukattash, Fernandes-Alnemri T, Shi Y, Jaynes JB, Alnemri ES. (2002). Sickle, a novel Drosophila death gene in the reaper/hid/grim region encodes an IAP-inhibitory protein. Curr Biol. 12: 125-30.
  29. Srinivasula SM, Zhan Y, Hegde R, Fernandes-Alnemri T, Alnemri ES, (2002). Death effector domain-containing proteins DEDD and Flame-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. 9: 439-47.
  30. Li W, Srinivasula SM, Chai J, Li P, Wu J-W, Zhang Z, Alnemri ES, Shi Y, (2002). Structure of the Mitochondrial Serine Protease HtrA2/Omi: Implications for its Pro-apoptotic Function. Nature Stuctural Biology 9: 436-41.
  31. Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA., Robbins PD, Fernandes-Alnemri T, Shi Y., Alnemri ES. (2001). A conserved XIAP-interaction motif in caspase-9 and Smac/Diablo regulates caspase activity and apoptosis. Nature. 410: 112-16.
  32. Srinivasula SM, Saleh A, Balkir L, Robbins PD, and Alnemri ES. (2000). Negative regulation of the Apaf-1 apoptosome by Hsp70. Nature Cell Biol 2: 476-483.
  33. Srinivasula SM., Ahmad M., Fernandes-Alnemri T., Alnemri ES., (1998). Autoactivation of Procaspase-9 by APAF-1-Mediated Oligomerization. Mol. Cell. 1: 949-957.
  34. Srinivasula SM., Ahmad M., MacFarlane M., Luo Z, Huang Z., Fernandes-Alnemri T., Alnemri ES., (1998). Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits. J Biol Chem. 273 : 10107-10111.
  35. Srinivasula SM, Ahmad M,Wang L, Litwack G, Fernandes-Alnemri T. and Alnemri ES. (1997), CRADD, a novel human apoptotic adaptor molecule for caspase-2 and FasL/TNF receptor-interacting protein RIP. Cancer Research.57, 615-619.
  36. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G. and Alnemri ES. (1996). Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3 /ICE-like cysteine proteases. Proc. Natl. Acad. Sci. USA. 93. 14486-14491.

Book Chapters:

1.    Fujita, K and Srinivasula SM. (2009). Ubiquitination and Death-receptor signaling. Death Receptors and Cognate Ligands in Cancer. Results Probl Cell Differ, SpringerLinks Publisher. 49: 87-114.

2.    Srinivasula SM, Saleh A, Ahmad M, Fernandes-Alnemri T, Alnemri ES. (2001). Isolation and Assay of Caspases. Ch. 1. Methods in Cell Biol. 66:1-27.