Jayaraman V, Saacnicteh Toledo*, Paola Lourino, Lianet Noda Garcia, 2022, Mechanisms in protein evolution. Protein Science, 31: e4362, https://doi.org/10.1002/pro.4362

Asutosh Bellur1, Soumik Das, Jayaraman V, Sudharshan Behera, Arpitha Suryavanshi, Sundaram Balasubramanian, Padmanabhan Balaram, Garima Jindal and Hemalatha Balaram, 2023, Revisiting the burden borne by fumarase: enzymatic hydration of an olefin. Biochemistry, 62 (2), 476-493, https://doi.org/10.1021/acs.biochem.2c00541

Elad N, Flamholz A, Jayaraman V, Ross B, Cohen Y, Patrick W, Gruic Ita, 2022, Uniform binding and negative catalysis in the origin of enzymes. Protein Science, 31, e4381, https://doi.org/10.1002%2Fpro.4381

Jayaraman V, Lee DJ, Elad N, Vimer S, Sharon M, Fraser J, Tawfik D. 2022, A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis. Nature Chemical Biology, 18, 161-170, https://doi.org/10.1038%2Fs41589-021-00919-y

Highlighted in Nature metabolism: https://www.nature.com/articles/s42255-022-00534-8

News and Views: https://www.nature.com/articles/s41589-021-00937-w

Press coverage: https://cen.acs.org/analytical-chemistry/structural-biology/Enzymes-opposite-functions-form-complex/100/web/2022/01

Jayaraman V, Suryavanshi A, Kalale. P, Kunala. J, Balaram H., 2018, Biochemical characterization and essentiality of Plasmodium fumarate hydratase. Journal of Biological chemistry, 293, 5878–5894, https://doi.org/10.1074/jbc.m117.816298

Jayaraman V; Bulusu V; Balaram. H., 2012, Crosstalk between purine nucleotide metabolism and mitochondrial pathways in Plasmodium falciparum. Current Science, 102 (5), 757-766, https://www.jstor.org/stable/24084462

Bulusu V, Jayaraman V, Balaram H.,2012, Metabolic fate of fumarate, a side product of the purine salvage pathway in the intra-erythrocytic stages of Plasmodium falciparum. Journal of Biological chemistry, 286, 9236–9245, https://doi.org/10.1074%2Fjbc.M110.173328

Jayaraman V*, Shafqat Ali Khan*, Kumar Perinbam*, Isha Rakheja, Abhinav Koyamangalath Vadakkepat, Santosh Kumar Chaudhary, Asheesh Kumar Pandey and Joydeep Mitra. 2023, Pathogenicity of non-toxigenic Vibrio cholerae and low-pH adaptation in the Vibrio phylum, BioRxiv, https://doi.org/10.1101/2023.02.13.528346

A Bellur, S Mukherjee, P Sharma, V Jayaraman, H Balaram, Enantioselectivity in the Enzymatic Dehydration of Malate and Tartrate: Mirror Image Specificities of Structurally Similar Dehydratases. bioRxiv (https://www.biorxiv.org/content/10.1101/2023.06.17.545066v1)

Protein structures solved

X-ray crystallography

Jayaraman V., Kunala, J., Balaram, H. Crystal structure of Methanocaldococcus jannaschii Fumarate hydratase beta subunit-5DNI. RCSB PDB, 2016. https://www.rcsb.org/structure/5DNI

Asutosh.B.R, Jayaraman V., Balaram, H. Crystal structure of Methanocaldococcus jannaschii fumarate hydratase heterodimer (7XKY); https://www.rcsb.org/structure/7XKY

Cryo-EM

Jayaraman, V., Lee, D.J., Elad, N., Fraser, J.S., Tawfik, D.S. Glutamate synthase, glutamate dehydrogenase counter-enzyme complex (GudB6-GltA6-GltB6). PDB ID: 7MFT, EMDataResource: EMD-23825. http://doi.org/10.2210/pdb7MFT/pdb

Jayaraman, V., Lee, D.J., Elad, N., Fraser, J.S., Tawfik, D.S. Glutamate synthase, glutamate dehydrogenase counter-enzyme complex (GudB6-GltA2-GltB2). PDB ID: 7MFM, EMDataResource: EMD-23817. http://doi.org/10.2210/pdb7MFM/pdb