Prof Nishant K. T
Professor (Biology)
  +91 (0)471 - 2778173

1. Suman Dash, Joshi S., Ajith, V.P., Shinohara A. and Nishant K.T (2023) Heterozygosity alters Msh5 binding to meiotic chromosomes in the baker's yeast. Genetics doi:

2. Fajish, G. V, Challa, K., Salim, S., VP, Ajith., Mwaniki, S., Zhang, R., Fujita, Y., Ito, M., Nishant, K. T*., & Shinohara, A. (2023) DNA double-strand breaks regulate the cleavage-independent release of Rec8-cohesin during yeast meiosis. Genes Cells 1–13. https:// (*Co-corresponding author)

3. Nishant K.T and Sanyal K (2023) Chromosome stability @10! (2023) Chromosoma doi: 10.1007/s00412-023-00795-6

4.  Michael Gioia*, Lisette Payero*, Sagar Salim, Ghanim Fajish V,  Amamah F. Farnaz, Gianno Pannafino, Jun Jie Chen, Ajith V.P, Sherikat Momoh, Michelle Scotland, Vandana Raghavan, Carol M. Manhart, Akira Shinohara, Nishant K.T and Eric Alani (2023) Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis. PLoS Biology  21(4):e3002085.  (* Equal contributors)  

5.  Krishnaprasad G. Nandanan*, Sagar Salim*, Ajith V. Pankajam*, Miki Shinohara, Gen Lin, Parijat Chakraborty, Amamah Farnaz, Lars M. Steinmetz, Akira Shinohara and Nishant K.T. (2021)  Regulation of Msh4-Msh5 association with meiotic chromosomes in yeast. Genetics  219(2):iyab102. doi: 10.1093/genetics/iyab102.  (* Equal contributors)  

6. Nishant K.T, Wloch-Salamon D, Wolfe K.H and Nobile C.J. (2021) Into the wild-Exploring the life cycles of yeasts. Yeast 38: 3-4.

7.  Sampaio, N.M.V., Ajith, V.P., Watson, R.A., Heasley, L.R., Chakraborty, P., Rodrigues-Prause, A., Malc, E.P., Mieczkowski, P.A., Nishant, K.T. and Argueso, J.L. (2020) Characterization of systemic genomic instability in budding yeast. PNAS USA, 117: 28221-28231.

8.  Ajith, V.P., Dash, S., Saifudeen, A., Dutta, A. and Nishant, K.T. (2020) Loss of heterozygosity and base mutation rates vary among Saccharomyces cerevisiae hybrid strains. G3 (Bethesda) 10: 3309-3319.

9. Giri, D.A., Ajith, V.P., Nishant, K.T. and Kasbekar, D.P (2019) The Neurospora crassa standard Oak Ridge background exhibits atypically efficient meiotic silencing by unpaired DNA. G3 (Bethesda) 9: 1487-1496. 

10.  Rodrigues-Prause, A., Sampaio, N.M.V., Gurol, T.M., Aguirre, G.M., Sedam, H.N.C., Chapman, M.J., Malc, E.P., Ajith, V.P., Chakraborty, P., Tizei, P.A., Pereira, G.A.G., Mieczkowski, P.A., Nishant, K.T. and Argueso JL (2018) A case study of genomic instability in an industrial strain of  Saccharomyces cerevisiae. G3 (Bethesda), 8: 3703-3713. 

11.  Chakraborty, P., Ajith, V.P., Dutta, A. and Nishant, K.T (2018) Genome wide analysis of meiotic recombination in yeast: for a few SNPs more.  IUBMB Life 70: 743-752.

12.  Dutta, A., Lin, G., Pankajam, A.V., Chakraborty, P., Bhat, N., Steinmetz, L.M. and Nishant K.T. (2017) Genome dynamics of hybrid Saccharomyces cerevisiae during vegetative and meiotic divisions.  G3 (Bethesda) 7: 3669-3679.

13.  Al-Sweel, N., Raghavan, V., Dutta, A., Ajith, V.P., Di Vietro, L., Khondakar, N., Manhart, C.M., Surtees, J.A., Nishant, K.T.* and Alani, E. (2017) Mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide. PLoS Genetics 13: e1006974. (*Co-corresponding author)

14.  Chakraborty, P., Pankajam, A.V.,  Lin, G., Dutta, A., Krishnaprasad, G.N., Tekkedil, M.M., Shinohara, A., Steinmetz, L.M. and Nishant K.T. (2017) Modulating Crossover Frequency and Interference for Obligate Crossovers in Saccharomyces cerevisiae Meiosis. G3 (Bethesda) 7: 1511-1524.

15.  Nishant K.T and Sanyal K. (2015) The Good, the bad, and the ugly: How to protect chromosome stability from potential threats. BioEssays 37: 717-720.

16. Krishnaprasad, G.N., Anand, M.T., Lin, G., Tekkedil, M.M., Steinmetz, L.M. and Nishant, K.T. (2015) Variation in crossover frequencies perturb crossover assurance without affecting meiotic chromosome segregation in Saccharomyces cerevisiae. Genetics 199: 399-412.

17. Rakshambikai, R., Srinivasan, N. and Nishant, K.T. (2013) Structural insights into Saccharomyces cerevisiae Msh4-Msh5 complex function using homology modeling. PLoS One 8: e78753.

18. Brown, M.S., Lim, E., Chen, C., Nishant, K.T. and Alani, E. (2013) Genetic Analysis of mlh3 Mutations Reveals Interactions Between Crossover Promoting Factors During Meiosis in Baker's Yeast. G3 (Bethesda) 3: 9-22.

19. Ma, X*., Rogacheva, M.V*., Nishant, K.T., Zanders, S., Bustamante, C.D., and Alani, E. (2012) Mutation hotspots in yeast caused by long-range clustering of homopolymeric sequences. Cell Reports 1: 36-42.* (Equal contributors)

20. Nishant, K.T*., Wei, W*., Mancera, E*., Argueso, L., Schlattl, A., Delhomme, N., Ma, X., Bustamante, C., Korbel, J., Gu, Z., Steinmetz, M. and Alani, E. (2010) The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis. PLoS Genetics 6:e1001109. (Featured in faculty of 1000) * (Equal contributors)

21. Nishant, K.T., Chen, C., Shinohara, M., Shinohara, A. and Alani, E. (2010) Genetic analysis of baker’s yeast MSH4-MSH5 reveals a threshold crossover level for meiotic viability. PLoS Genetics 6: e1001083

22.  Agrawal, S., Nishant, K.T. and Rao, M.R.S (2010) Analysis of Meiotic Recombination Hotspots: A Bioinformatics Approach, In Gabriel Fung's,  A Practical Guide to Bioinformatics Analysis (pp. 133-149) Queensland, Australia: iConcept Press. (Book chapter)

23. Nishant, K.T., Singh, N. and Alani, E. (2009) Genomic mutation rates: What highthroughput methods can tell us. Bioessays 31: 912-920.

24. Nishant, K.T., Plys, A. and Alani, E. (2008) A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae. Genetics 179: 747-755 (featured in Issue highlights)

25. Nishant, K.T., Kumar, C. and Rao, M.R.S (2006) HumHot: A database of human meiotic recombination hot spots. Nuc.Acids.Res. 34: D25-D28.

26. Nishant, K.T. and Rao, M.R.S. (2006) Molecular features of meiotic recombination hot spots. BioEssays 28: 45-56.

27. Nishant, K.T., Ravishankar, H. and Rao, M.R.S. (2004) Characterization of a mouse recombination hotspot encoding a novel non-protein coding RNA. Mol.Cell.Biol. 24: 5620 - 5634.