Dr Reji Varghese
Associate Professor (Chemistry)
  +91 (0)471 - 2778074

48. Multifunctional siRNA/ferrocene/cyclodextrin nanoparticles for enhanced chemodynamic cancer therapy

      Gowtham Raj, D. S. Vasudev, Sarah Christopher, Anupama Babulal, P. Harsha, Soumakanya Ram, Mehul Tiwari, Markus Sauer and                    Reji Varghese

      Nanoscale, 2024, 16, 3755


47. Antisense DNA loaded 2D nanosheets for combined photodynamic and antisense cancer therapy

      Gowtham Raj, Vasudev D. S, Justin Prasad, Erai Anbu, Soumakanya Ram, Geoffrey Bellson Daniel, Nikhil Dev Narendradev,  Srinivasa            Murty Srinivasula and Reji Varghese

      Mater. Chem. Front., 2024, 8, 553




46. Adamantoid Scaffolds for Multiple Cargo Loading and Cellular Delivery as β-Cyclodextrin Inclusion Complexes

     Arthi Ravi, Atchutarao Pathigoolla, Haripriya Balan, Ria Gupta, Gowtham Raj, Reji Varghese, and Kana M. Sureshan 

     Angew. Chem.Int. Ed.2023,62,  e20230732 


45.19F NMR ON/OFF nanoparticles: a universal approach for the specific detection of DNA-binding cancer biomarkers

     Devanathan Perumal, Jithu Krishna, Kaloor S Harikrishnan, Gowtham Raj, Jemshiya Kalathil, Minu Saji, M Kavyasree, Reji Varghese

      Nanoscale, 2023, 15, 8972


44. Tumor microenvironment responsive nanocarriers for efficient antisense DNA delivery and enhanced chemodynamic therapy

      Gowtham Raj, DS Vasudev, Nikhil Dev Narendradev, Viswa Kalyan Kumar Dommeti, Saurabh Shriwas, PM Ajay Sekhar

      Leah Susan Jacob, S Murty Srinivasula, Reji Varghese

       Mater. Chem. Front., 2023, 7, 1821



43. Supramolecular grafting of stimuli-responsive, carrier-free, self-deliverable nanoparticles of camptothecin and antisense DNA for

       combination cancer therapy

     Devanathan Perumal, Jemshiya Kalathil, Jithu Krishna, Gowtham Raj, Kaloor S Harikrishnan, ML Uthpala, Ria Gupta, Reji Varghese

     New J. Chem., 2022, 46, 16813

42. G4-Quartet hydrogel loaded with doxorubicin and hemin for cascade chemodynamic therapy

      Gowtham Raj, Viswa Kalyan Kumar Dommeti, Vinayak Pradeep, Abhindev Kizhakke Veetil and Reji Varghese

       Mater. Chem. Front., 2022, 6, 1533

41. Galactose-Grafted a Scaffold for the In Situ Synthesis of Silver Nanoparticles A Potential Catalyst for the Reductionof Nitroaromatics

      Kaloor S Harikrishnan, Nithiyanandan Krishnan, Nilima Manoj Kumar, Anusree Krishna, Gowtham Raj, Devanathan Perumal,

     Jemshiya Kalathil, Jithu Krishna, Reji Varghese

      Chem.Eur.J.2021,27,   14100–14107

40. Blue-emissive two-component supergelator with aggregation-induced enhanced emission

      Swathi Vanaja Chandrasekharan, Nithiyanandan Krishnan, Siriki Atchimnaidu, Gowtham Raj, Anusree Krishna PK, Soumya Sagar,

      Suresh Das, Reji Varghese

      RSC Adv., 2021, 11, 19856



39. Biotin-decorated NIR-absorbing nanosheets for targeted photodynamic cancer therapy

     Devanathan Perumal, Murali Golla, Kavya S Pillai, Gowtham Raj, Anusree Krishna PK, Reji Varghese

     Org. Biomol. Chem., 2021, 19, 2804


38. DNA−π Amphiphiles: A Unique Building Block for the Crafting of DNA-Decorated Unilamellar Nanostructures

     Shine K Albert, Murali Golla, Nthiyanandan Krishnan, Devanathan Perumal, Reji Varghese

     Acc. Chem. Res. 2020, 53, 11, 2668–2679

37. Efficient Capturing of Polycyclic Aromatic Micropollutants From Water Using Physically Crosslinked DNA Nanoparticles   

      Siriki Atchimnaidu, Hari Veera Prasad Thelu, Devanathan Perumal, Kaloor S Harikrishnan, Reji Varghese

       Frontiers in Chemistry                                                                                                                                                                                                                                                                             

36. Galactose-Grafted 2D Nanosheets from the Self-Assembly of Amphiphilic Janus Dendrimers for the Capture and Agglutination of Escherichia coli

Nithiyanandan Krishnan, Devanathan Perumal, Siriki Atchimnaidu, Kaloor S. Harikrishnan, Murali Golla, Nilima Manoj Kumar, Jemshiya Kalathil, Jithu Krishna, Dileep K. Vijayan and Reji Varghese* Chem.Eur.J.2020,26,1037 –1041

35. Phototheranostic DNA micelles from the self-assembly of DNA-BODIPY amphiphiles for the thermal ablation of cancer cells

Siriki Atchimnaidu, Devanathan Perumal, Kaloor S. Harikrishanan, Hari Veera Prasad Thelu and Reji Varghese *  

Nanoscale. 2020, DOI:  10.1039/d0nr02622k


34. Self-Assembly of an Aptamer-Decorated, DNA−Protein Hybrid Nanogel: A Biocompatible Nanocarrier for Targeted Cancer Therapy

     Hari Veera Prasad Thelu, Siriki Atchimnaidu, Devanathan Perumal, Kaloor S. Harikrishnan, Shajesh Vijayan, and Reji Varghese* 

      ACS Appl. Bio Mater. 2019, DOI: 10.1021/acsabm.9b00323                                                                                                                                                                                       

33. DNA-Decorated Helically Twisted Nanoribbon: A Scaffold for the Fabrication of One-Dimensional Chiral Plasmonic Nanostructures
Murali Golla, Shine K. Albert, Devanathan Perumal, Siriki Atchimnaidu, Nithiyanandan Krishnan and Reji Varghese*
Angew. Chem. Int. Ed., 2019, 58, 3865–3869



32. Self-assembly of tetraphenylethylene based dendron into blue fluorescent nanoparticles with aggregation induced enhanced emission
Nithiyanandan Krishnan, Hanna Ameena M. A., Siriki Atchimnaidu, Devanathan Perumal, Murali Golla, Jithu Krishna and Reji Varghese*
J. Chem. Sci., 2018, (accepted) (invited article)


31. Aptamer Decorated DNAsome for Targeted Cancer Therapy
Murali Golla, Sai Praveen Thadi, Devanathan Perumal, Siriki Atchimnaidu,and Reji Varghese*
ChemNanoMat, 2018, DOI: 10.1002/cnma.201800297


30. Self-assembly of DNA-tetraphenylethylene amphiphile into DNA-grafted nanosheet as a support for the immobilization of gold nanoparticles: A recyclable catalyst with enhanced activity
Nithiyanandan Krishnan, Murali Golla, Hari Veera Prasad Thelu, Shine K. Albert, Siriki Atchimnaidu, Devanathan Perumal and Reji Varghese*
Nanoscale, 2018, DOI: 10.1039/C8NR03746A


29. Size controllable DNA nanogels from the self-assembly of DNA nanostructures through multivalent host–guest interactions
Hari Veera Prasad Thelu, Shine K. Albert, Murali Golla, Nithiyanandan Krishnan, Divya Ram, S. Murty Srinivasula and Reji Varghese*
Nanoscale, 2018, 10, 222–230


28. DNA-Decorated Two-Dimensional Crystalline Nanosheets
Shine K. Albert, Irla Sivakumar, Murali Golla, Hari Veera Prasad Thelu, Nithiyanandan Krishnan, Joseph Libin K. L., Ashish, and Reji Varghese*
J. Am. Chem. Soc.2017, 139, 17799–17802


27. A pH-responsive DNAsome from the self-assembly of DNA-phenyleneethynylene hybrid amphiphile
Shine K. Albert, Hari Veera Prasad  Thelu, Murali Golla, Nithiyanandan Krishnan, Reji Varghese*
Chem. Eur. J. 2017,23, 8348–8352


26. Modular Synthesis of Supramolecular DNA Amphiphiles through Host-guest Interactions and their Self-assembly into DNA-decorated Nanovesicles
Shine K. Albert, Hari Veera Prasad  Thelu, Murali Golla, Nithiyanandan Krishnan, Reji Varghese*
Nanoscale 2017, 9, 5425-5432.


25. DNA-Decorated Luminescent Vesicles as Drug Carriers
Hari Veera Prasad Thelu, Shine K. Albert, Murali Golla, Nithiyanandan Krishnan, Santosh Bhargav Yamijala, Sreeja V. Nair, S. Murty Srinivasula,* Reji Varghese*
ChemistrySelect 2016, 1, 5389 – 5396. (DOI: 10.1002/slct.201600897)


24. Synthesis and self-assembly of DNA–chromophore hybrid amphiphiles
Shine K. Albert, Murali Golla, Hari Veera Prasad Thelu, Nithiyanandan Krishnan, Perapaka Deepak and Reji Varghese*
Org. Biomol. Chem2016, 14, 6960. (DOI: 10.1039/c6ob00681g)


23. DNA-Based Oligochromophores as Light-Harvesting Systems?
P. Ensslen, F. Brandl, S. Sezi, R. Varghese, R.-J. Kutta, B. Dick, H.-A. Wagenknecht*  
Chem. Eur. J. 2015, 21, 9349.  pub231.gif


22. Self-Assembly of DNA–Oligo(p-phenylene-ethynylene) Hybrid Amphiphiles into Surface-Engineered Vesicles with Enhanced Emission
Shine K. Albert, Hari Veera Prasad Thelu, Murali Golla, Nithiyanandan Krishnan, Soma Chaudhary, and Reji Varghese*
Angew. Chem. Int. Ed. 2014, 53, 8352-8357. (DOI: 10.1002/anie.201403455)



21. Conformational Control of Dual Emission by Pyrrolidinyl PNA-DNA Hybrids 
S. Sezi, R. Varghese, T. Vilaivan, H.-A.Wagenknecht*
ChemistryOpen2012, 1, 173.


20. Oligo(p-phenyleneethynylene)Derived Super -Gelators with TunableEmission and Self-assembled Polymorphic Structures
Anesh Gopal, Dr. Reji Varghese and Ayyappanpillai Ajayaghosh*
Chem. Asian J. 2012, 7, 1963. (DOI: 10.1002/asia.201290035)(coverpage)



19. Site-specific synthesis and in situ immobilization of fluorescent silver nanoclusters on DNAnanoscaffolds by use of the Tollens reaction
S. Pal, R. Varghese, Z. Deng, Z. Zhao, A.Kumar, Y. Liu,* H. Yan*
Angew. Chem. Int. Ed. 2011, 50, 4176. (DOI: 10.1002/anie.201007529)


18. DNA directed artificial light harvesting antenna
P. K. Dutta, R. Varghese, J.Nangreave, S. Lin, H. Yan,* Y. Liu*
J. Am. Chem. Soc. 2011, 133, 11985-11993. (DOI: 10.1021/ja1115138)



17. Non-covalent versus Covalent Control of Self-assembly and Chirality of Nile Red-modified Nucleoside and DNA
R. Varghese, H.-A. Wagenknecht*
Chem. Eur. J. 2010, 16, 9040 – 9046. (DOI: 10.1002/chem.201001136)


16. Red-White-Blue Emission Switching Molecular Beacons: Ratiometric Multicolour DNA Hybridization Probes
R. Varghese, H.-A. Wagenknecht*
Org. Biomol. Chem. 2010, 3, 526. (DOI: 10.1039/b918381g)



15. White-Light-Emitting DNA (WED)
R. Varghese, H.-A. Wagenknecht*,
Chem. Eur. J. 2009, 15, 9307 (with cover page), (DOI: 10.1002/chem.200990142)


14. Synthesis and Optical Properties of Nile Red Modified 2?-Deoxyuridine and 7-Deaza-2?-deoxyadenosine: Highly Emissive Solvatochromic Nucleoside
R. Varghese, P. K. Gajula, T. K. Chakraborty, H.-A. Wagenknecht*
Synlett 2009, 3252. (DOI: 10.1055/s-0029-1218384)


13. DNA as a supramolecular framework for the helical arrangements of chromophores: towards photoactive DNA-based nanomaterials
R. Varghese, H.-A. Wagenknecht*
Chem. Commun. 2009, 19, 2615. (DOI: 10.1039/B821728A) (Feature Article)



12. Helical Supramolecular Architectures of Self-Assembled Linear ?-Systems
V. K. Praveen, S.S. Babu, C. Vijayakumar, R. Varghese, A. Ajayaghosh*
Bull. Chem. Soc. Jpn. 2008, 81, 1196. (DOI: http://dx.doi.org/10.1246/bcsj.81.1196)


11. Solvent Induced Aggregation and Cation Controlled Self-assembly of Tripodal Squaraine Dyes: Optical, Chiroptical and Morphological Properties
P. Chithra, R. Varghese, K. P. Divya, A. Ajayaghosh*
Chem. Asian J. 2008, 3, 1365. (DOI: 10.1002/asia.200800133)


10. Controlled self-assembly of squaraines to 1D supramolecular architectures with high molar absorptivity
A. Ajayaghosh*, P. Chithra, R. Varghese, K. P. Divya
Chem. Commun. 2008, 969. (DOI: 10.1039/b718054c)



9. Quadrupolar ?-Gels: Sol-Gel Tunable Red-Green-Blue (RGB) Emission in Donor-Acceptor Type Oligo(p-phenylenevinylene)s,
A. Ajayaghosh* V. K. Praveen, S. Srinivasan, R. Varghese
Adv. Mater. 2006, 19, 411. (DOI: 10.1002/adma.200601500)


8. Self-Assembly of Tripodal Squaraines: Cation Assisted Expression of Molecular Chirality and Spherical to Helical Morphology Change
A. Ajayaghosh*, P. Chithra, R. Varghese
Angew. Chem. Int. Ed. 2006, 45, 230. (DOI: 10.1002/anie.200603611)


7. Vesicles to Helical Nanotubes: An Unprecedented “Sergeant and Soldiers” Effect in the Selfassembly of Oligo(p-phenyleneethynylene)s
A. Ajayaghosh*, R. Varghese, S. Mahesh, V. K. Praveen
Angew. Chem. Int. Ed. 2006, 45, 7729. (DOI: 10.1002/anie.200603238)


6. Self-Assembled ?-Nanotapes as Donor Scaffolds for Selective and Thermally Gated Fluorescence Resonance Energy Transfer (FRET)
V. K. Praveen, S. J. George, R. Varghese, C. Vijayakumar, A. Ajayaghosh*
J. Am. Chem. Soc. 2006, 128, 7542. (DOI: 10.1021/ja0587594)


5. Self-Location of Acceptors as “Isolated” or “Stacked” Energy Traps in a Supramolecular Donor Self-Assembly:
A Strategy to Wavelength Tunable FRET Emission
A. Ajayaghosh*, C. Vijayakumar, V. K. Praveen, S. S. Babu, R. Varghese
J. Am. Chem. Soc. 2006, 128, 7174. (DOI: 10.1021/ja0621905)


4. Evolution of Nano- to Microsized Spherical Assemblies of a Short Oligo(p-phenyleneethynylene) into Superstructured Organogels
A. Ajayaghosh*, R. Varghese, V. K. Praveen, S. Mahesh
Angew. Chem. Int. Ed. 2006, 45, 3261. (DOI: 10.1002/anie.200600256)


3. Transcription and Amplification of Molecular Chirality to Oppositely Biased Supramolecular ?-Helices
A. Ajayaghosh*, R. Varghese, S. J. George, C. Vijayakumar
Angew. Chem. Int. Ed. 2006, 45, 1141. (VIP with cover picture; DOI: 10.1002/anie.201201268)


2. Cholesterol-Aided Supramolecular Control over Chromophore Packing: Twisted and Coiled Helices with Distinct Optical, Chiroptical and Morphological Properties
A. Ajayaghosh*, C. Vijayakumar, R. Varghese, S. J. George
Angew. Chem. Int. Ed. 2006, 45, 456. (VIP) (DOI: 10.1002/anie.200503258)


1. Anion Induced Modulation of Self-Assembly and Optical Properties in Urea Endcapped Oligo(p-phenylenevinylene)s
R. Varghese, S.J. George, A. Ajayaghosh*
Chem. Commun. 2005, 593. (DOI: 10.1039/B413909G)